Given the immense progress achieved in elucidating protein protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein protein interactions from the analysis of protein protein complex structures and interfaces. What are the driving forces for protein protein association? How can we extract the mechanism of specific recognition from studying protein protein interfaces? How can this knowledge be used to predict and design protein protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein protein interactions, and how can we influence protein protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?

Drug Disposition and Pharmacokinetics, is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. This book provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus.

In the 1980s, Miami was a playground for the rich and famous. But behind the fun in the sun, an underground cocaine war was escalating. South American drug cartels would forever change the face of sunny Miami.

This series will trace the history, describe the invention or discovery, generally for honorable reasons, and the transition to illegal and recreational use.
Contains 4 books: Cocaine & Heroin by Julian Durlacher; Ecstasy & Speed by Miriam Joseph.

The most widely associated perception of Straight Edge involves abstinence from alcohol, tobacco, other drugs and promiscuous sex. Since it s origin in the early 1980 s these beliefs have spread all over the world, connected through the Punk and Hardcore music scenes. Through interviews with musicians that directly shaped the idea of Straight Edge from its inception until today, EDGE reveals that the abstinence from drugs was established as a youth counter culture rejecting a society dominated by substance abuse and hegemony. Ian MacKaye (Minor Threat, Fugazi), Ray Cappo (Youth of Today, Shelter) and Karl Buechner (Earth Crisis, Freya) give witness to their perception of the history of Straight Edge, why it was so important to them and what it changed in their personal and professional careers. But they also address problems like violence, sexism and intolerance that emerged within Straight Edge...