A group of five college kids are forced to match wits with unwelcoming residents when they fly to a deserted island for a party weekend..

After being attacked by some of his fellow Breed, Ray Stoner realizes he can no longer hide from what he is: a monster. He returns to the mystical city Elsewhere and discovers much has changed. The struggle he is unwillingly part of has become extremely more dangerous and the stakes astronomically higher.

When the bad boy John inherits an isolated house in an island, he invites his brother and student of veterinary Matt and his girlfriend Nikki together with their common friends Sara and Noah to fly with him in his hydroplane and spend a couple of days having good time in the place. Later Sara is attacked by a dog and they recall that in the other side of the island there was a facility for training dogs that had been shutdown to avoid a rabies outbreak. While walking through the woods, they find a man called Luke, who sailed with his girlfriend Jenny to the island, covered of blood and Luke is killed by a pack of hounds. The group runs to the house and the animals put the place under siege, and they try to find a means of escape. When the survivors reach the compound, they disclose that the dogs have been genetically redesigned to become a breed of killers.

Every day, migrating creatures around the world wage incredible journeys; risking it all in pursuit of the one thing more precious than themselves: the creation and caretaking of their precious young - the next generation of global wanderers. From the rocky beaches of the Falkland Islands to the dense forests of Costa Rica and Australia to the desolate savannah of southern Sudan, countless animals now venture forth on timeless journeys, bent on their own survival -- and the survival of their species.